In 2010 the three counties in which Indian reservations exist had the largest proportion of Native American residents. Washington leads with 4.5 percent of the county’s population. Aroostook (1.5%) and Penobscot (.9%) follow. The Native American population statewide is 0.6%.
| County | Percent |
| Washington | 4.5% |
| Aroostook | 1.5% |
| Penobscot | 0.9% |
| Piscataquis | 0.6% |
| Kennebec | 0.5% |
| Somerset | 0.5% |
| Androscoggin | 0.4% |
| Cumberland | 0.4% |
| Franklin | 0.4% |
| Hancock | 0.4% |
| Oxford | 0.4% |
| Sagadahoc | 0.4% |
| Waldo | 0.4% |
| Knox | 0.3% |
| Lincoln | 0.3% |
| York | 0.3% |
Source: U.S. Bureau of Census